chemical properties of urease

Urease is a white fine crystalline powder. It is soluble in water and insoluble in organic solvents such as alcohol, ether and acetone. The isoelectric point is 5.0 to 5.1, and the optimum ph is 8.0. Enzyme activity is inhibited by heavy metal ions. It catalyzes the hydrolysis of urea to ammonia and carbon dioxide. It stimulates the body to produce urease antibodies. It can inhibit urease activity in the gastrointestinal tract, thereby reducing urea hydrolysis and reducing blood ammonia, so as to prevent liver coma.


Use Urease prevents hepatic coma. The urease microcapsules and the ion exchange resin microcapsule adsorbent constitute an artificial kidney. It is used to lower non-protein nitrogen in the blood. Urease is used in biochemical research and is often used clinically as a diagnostic enzyme for the determination of urea in blood and urine. Urease is used to decompose residual urea in wine and inhibit the formation of urethane. Urease analysis is used to measure urea in blood and urine. Urease is also used in medicine, immunotherapy for hepatic coma, preparation of new artificial kidneys, and urine microsensors.

Production method 1 The non-pathogenic, non-toxigenic bacterium, Lactobacillus frmentum, was isolated from pure cultures of various culture materials of GR.AS.

Production method 2 The bean powder is used as a raw material, extracted by acetone, filtered, centrifuged, and recrystallized to obtain a product.

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